Monthly Archives: August 2021
775f The Introduction of Faecal Immunochemical Testing as a Triaging Tool for Colorectal Cancer Investigation During the COVID-19 Pandemic. A Service Evaluation and Report.
The covid-19 pandemic has caused unprecedented difficulties within GI endoscopy. In the UK, this has included a five-week suspension of all non-emergency endoscopy from March 2020, followed by a prolonged recovery period. Endoscopy activity remains at … Continue reading
775e Active Herpes Simplex Virus Type 1 Infection of the Gastric Mucosa is Associated with Functional Gastrointestinal Disorders: A Pilot Case-Control Study
Neurotropic herpes viruses establish lifelong latent infections in ganglionic neurons, including intrinsic enteric neurons and extrinsic neurons that project to the GI tract. Upon reactivation, virus replication within innervated tissues can result in … Continue reading
PTG-100, an Oral α4β7 Antagonist Peptide: Preclinical Development and Phase 1 and 2a Studies in Ulcerative Colitis
Oral therapies targeting the integrin α4β7 may offer unique advantages for treatment of inflammatory bowel disease. We characterized the oral α4β7 antagonist peptide PTG-100 in preclinical models, and established safety, pharmacokinetic/pharmacodynamic… Continue reading