Daily Archives: September 1, 2021

Molecular characterization of limited ulcerative colitis reveals novel biology and predictors of disease extension

Disease extent varies in ulcerative colitis (UC) from proctitis to left-sided colitis to pancolitis and is a major prognostic factor. When the extent of UC is limited there is often a sharp demarcation between macroscopically involved and uninvolved ar… Continue reading

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Single cell DNA sequencing reveals punctuated and gradual clonal evolution in hepatocellular carcinoma

Copy number alterations (CNAs), elicited by genome instability, is a major source of intratumor heterogeneity. How CNAs evolve in hepatocellular carcinoma (HCC) remains unknown. Continue reading

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