The mucosa of the body of the stomach (i.e., the gastric corpus) employs two overlapping, depth-dependent mechanisms to respond to injury. Superficial injury heals via surface cells with histopathological changes like foveolar hyperplasia. Deeper, usually chronic, injury/inflammation, most frequently induced by the carcinogenic bacteria H pylori, elicits glandular histopathological alterations, initially manifesting as pyloric (also known as pseudopyloric) metaplasia. In this pyloric metaplasia, corpus glands become antrum (pylorus)-like with loss of acid-secreting parietal cells (atrophic gastritis), expansion of foveolar cells, and reprogramming of digestive enzyme-secreting chief cells into deep antral gland-like, mucous cells.