Monthly Archives: October 2021
Prolonged impairment of short-chain fatty acid and L-isoleucine biosynthesis in gut microbiome in patients with COVID-19
SARS-CoV-2 infection is associated with altered gut microbiota composition. Phylogenetic groups of gut bacteria involved in the metabolism of short chain fatty acids were depleted in SARS-CoV-2-infected patients. We aimed to characterize functional pro… Continue reading
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Loss of Endothelial TSPAN12 Promotes Fibrostenotic Eosinophilic Esophagitis via Endothelial Cell–Fibroblast Crosstalk
Eosinophilic esophagitis (EoE) can progress to fibrostenosis by unclear mechanisms. Herein, we investigated gene dysregulation in fibrostenotic EoE, its association with clinical parameters and specific pathways, and the functional consequences. Continue reading
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Comparing colorectal cancer screening outcomes in the International Cancer Screening Network (ICSN): A Consortium proposal
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Connecting the dots: Dietary fat, microbiota dysbiosis, altered metabolome and colon cancer
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Burden and Cost of Gastrointestinal, Liver, and Pancreatic Diseases in the United States: Update 2021
Gastrointestinal diseases account for considerable health care use and expenditures. We estimated the annual burden, costs, and research funding associated with gastrointestinal, liver, and pancreatic diseases in the United States. Continue reading
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New role for fatty acid receptor regulation of immune cells to control intestinal inflammation
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Timeline of development of pancreatic cancer and implications for successful early detection in high-risk individuals
To successfully implement imaging-based pancreatic cancer (PC) surveillance, it is key to understand the timeline and morphological features of neoplastic progression. We aimed to investigate the progression to neoplasia from serial prediagnostic pancr… Continue reading
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Clinical Management of Pancreatic Premalignant Lesions
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MicroRNA-15a/16-1 Prevents Hepatocellular Carcinoma by Disrupting the Communication between Kupffer Cells and Tregs
Hepatocellular carcinoma (HCC) is characterized by intratumoral accumulation of regulatory T-cells (Tregs), which suppresses antitumor immunity. This study was designed to investigate how microRNAs regulate immunosuppression in HCC. Continue reading
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STRAP: a Bridge between Mutant APC and Wnt/ß-Catenin Signaling in Intestinal Cancer
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