Monthly Archives: October 2021
Uniting the Global Gastroenterology Community to Meet the Challenge of Climate Change and Non-Recyclable Waste
Climate change has been described as the biggest global health threat of the 21st century1 and has significant implications for gastrointestinal (GI) health and disease,2 which is the focus of this consensus commentary provided by the World Gastroenter… Continue reading
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Activating Immune Recognition in Pancreatic Ductal Adenocarcinoma via Autophagy Inhibition, MEK blockade and CD40 Agonism
Pancreatic ductal adenocarcinoma (PDA) patients have not yet benefitted from the revolution in cancer immunotherapy due in large part to a dominantly immunosuppressive tumor microenvironment (TME). MEK inhibition combined with autophagy inhibition lead… Continue reading
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CME Exam 1: The Tight Junction Protein ZO-1 Is Dispensable for Barrier Function But Critical for Effective Mucosal Repair
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Host-microbiota interactions in the esophagus during homeostasis and allergic inflammation
Microbiota composition and mechanisms of host-microbiota interactions in the esophagus are unclear. Herein, we aimed to uncover fundamental information about the esophageal microbiome and its potential significance to eosinophilic esophagitis (EoE). Continue reading
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Incidence and mortality in upper gastrointestinal cancer after negative endoscopy for gastroesophageal reflux disease
Gastroesophageal reflux disease (GERD) is associated with an increased risk of cancer of the upper gastrointestinal tract. This study aimed to assess whether and to what extent a negative upper endoscopy in patients with GERD is associated with a decre… Continue reading
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COVID-19 mRNA Vaccine Short-Term Safety in Patients with Inflammatory Bowel Disease
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“Going the extra mile”: A Sox10 target, Cdh19, is Required for Sacral NC Migration in ENS Development
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“Going the extra mile”: A Sox10 target, Cdh19, is Required for Sacral NC Migration in ENS Development
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Single Cell DNA Sequencing Reveals Chromosomal Diversity in HCC and a Novel Model of HCC Evolution
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Epidemiology, etiology and treatment of gastroparesis: real-world evidence from a large US national claims database
While gastroparesis carries a considerable healthcare and patient burden, associated epidemiological data are limited. To provide new real-world evidence for gastroparesis, we estimated disease prevalence, and investigated patient demographics and dise… Continue reading
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