The Rome criteria, which define Disorders of Gut-Brain Interaction (DGBIs), are extensively applied in epidemiological research, pathophysiological studies, treatment trials, and clinical practice. The requirement for long periods of symptom presence and high symptom frequencies facilitated the use of the Rome criteria in epidemiology studies and treatment trials but has hampered clinical application when these requirements were not fulfilled. The Rome Foundation proposes a modification of the diagnostic criteria for clinical practice, where a DGBI diagnosis can still be made if 1) the nature of symptoms corresponds to those in the DGBI Rome IV diagnostic criteria, and 2) symptoms are bothersome (interfering with daily activities or requiring attention, causing worry or interference with quality of life).