Monthly Archives: December 2021
How to approach a patient with gastric varices?
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CME Exam 2: A Clinical Approach to Chronic Diarrhea
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CME Exam 1: Adenoma Detection Rates for 45- to 49-Year-Old Screening Population
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Covering the Cover
Spermidine reduces colitis and colonic carcinogenesis in mice models. Continue reading
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Loss of Rnf43 accelerates Kras-mediated neoplasia and remodels the tumor immune microenvironment in pancreatic adenocarcinoma
RNF43 is an E3 ubiquitin ligase that is recurrently mutated in pancreatic ductal adenocarcinoma (PDAC) and precursor cystic neoplasms of the pancreas. The impact of RNF43 mutations on PDAC is poorly understood and autochthonous models have not been suf… Continue reading
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Intestinal Cathelicidin Antimicrobial Peptide Shapes a Protective Neonatal Gut Microbiota against Pancreatic Autoimmunity
Alteration of the gut microbiota is implicated in the development of autoimmune type 1 diabetes (T1D), as shown in humans and the non-obese diabetic (NOD) mouse model. However, how gut dysbiosis arises and promotes the autoimmune response remains an op… Continue reading
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Clonal transitions and phenotypic evolution in Barrett esophagus
Barrett esophagus (BE) is a risk factor for esophageal adenocarcinoma but our understanding of how it evolves is poorly understood. We investigated BE gland phenotype distribution, the clonal nature of phenotypic change and how phenotypic diversity pla… Continue reading
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N6-methyladenosine reader YTHDF1 promotes ARHGEF2 translation and RhoA signaling in colorectal cancer
N6-methyladenosine (m6A) governs the fate of RNAs through m6A readers. Colorectal cancer (CRC) exhibits aberrant m6A modifications and expression of m6A regulators. However, how m6A readers interpret oncogenic m6A methylome to promote malignant transfo… Continue reading
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Liver Tumor post Liver Transplantation for Hepatitis C Cirrhosis: An Unusual Cause
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Clinical and Endoscopic Characteristics Associated with Post-Endoscopy Upper Gastrointestinal Cancers: a Systematic Review and Meta-analysis
Ten percent of patients with an upper gastrointestinal cancer will have received an esophagogastroduodenoscopy (EGD) within three years prior to diagnosis, termed post-endoscopy upper gastrointestinal cancers (PEUGIC). We aimed to determine the charact… Continue reading
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