Daily Archives: December 21, 2021
MNX1-HNF1B axis is indispensable for intraductal papillary mucinous neoplasm lineages
Chromatin architecture governs cell lineages by regulating the specific gene expression; however, its role in the diversity of cancer development remains unknown. Among pancreatic cancers, pancreatic ductal adenocarcinoma (PDAC) and intraductal papilla… Continue reading
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Molecular signature predictive of long-term liver fibrosis progression to inform anti-fibrotic drug development
There is a major unmet need to assess the prognostic impact of anti-fibrotics in clinical trials due to the slow rate of liver fibrosis progression. We aimed to develop a surrogate biomarker to predict future fibrosis progression. Continue reading
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Inadequate Rectal Pressure and Insufficient Relaxation and Abdominopelvic Coordination in Defecatory Disorders
Diagnostic tests for defecatory disorders (DDs) asynchronously measure anorectal pressures and evacuation and show limited agreement; thus, abdominopelvic-rectoanal coordination in normal defecation and DDs is poorly characterized. We aimed to investig… Continue reading
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