Monthly Archives: December 2021
MNX1-HNF1B axis is indispensable for intraductal papillary mucinous neoplasm lineages
Chromatin architecture governs cell lineages by regulating the specific gene expression; however, its role in the diversity of cancer development remains unknown. Among pancreatic cancers, pancreatic ductal adenocarcinoma (PDAC) and intraductal papilla… Continue reading
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Molecular signature predictive of long-term liver fibrosis progression to inform anti-fibrotic drug development
There is a major unmet need to assess the prognostic impact of anti-fibrotics in clinical trials due to the slow rate of liver fibrosis progression. We aimed to develop a surrogate biomarker to predict future fibrosis progression. Continue reading
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Inadequate Rectal Pressure and Insufficient Relaxation and Abdominopelvic Coordination in Defecatory Disorders
Diagnostic tests for defecatory disorders (DDs) asynchronously measure anorectal pressures and evacuation and show limited agreement; thus, abdominopelvic-rectoanal coordination in normal defecation and DDs is poorly characterized. We aimed to investig… Continue reading
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Stem Cells, Helicobacter pylori and Mutational Landscape – Utility of Pre-Clinical Models to Understand Carcinogenesis and to direct Management of Gastric Cancer
Several genetic and environmental factors increase gastric cancer (GC) risk, with Helicobacter pylori being the main environmental agent. GC is thought to emerge through a sequence of morphological changes that have been elucidated on the molecular lev… Continue reading
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Patients with Adenocarcinoma of the Esophagus or Esophagogastric Junction Frequently Have Potential Screening Opportunities
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Racism is a Modifiable Risk Factor: Relationships Between Race, Ethnicity, and Colorectal Cancer Outcomes
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Advancing health equity for Medicaid beneficiaries by adding colorectal cancer screening to the CMS Adult Core Set
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BZW1 Facilitates Glycolysis and Promotes Tumor Growth in Pancreatic Ductal Adenocarcinoma Through Potentiating eIF2α Phosphorylation
Pancreatic ductal adenocarcinoma (PDAC) is characterized by severe metabolic stress due to fibrosis and poor vascularization. BZW1 is an eIF5-mimic protein involved in tumorigenesis and progression. The aim of this study was to investigate the role of … Continue reading
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