Monthly Archives: December 2021
The origin and contribution of cancer-associated fibroblasts in colorectal carcinogenesis
Cancer-associated fibroblasts (CAFs) play an important role in colorectal cancer (CRC) progression and predict poor prognosis in CRC patients. However, the cellular origins of CAFs remain unknown, making it challenging to therapeutically target these c… Continue reading
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Covering the cover – Holmberg et al
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In Memoriam: Tadataka “Tachi” Yamada, MD, 1945–2021
The gastroenterology community mourns the loss of Tadataka “Tachi” Yamada, who passed away on August 4, 2021, at the age of 76 years. He is survived by Leslie, his beloved wife of 54 years; his children, Sanae and Takeo, and their spouses; his 4 grandc… Continue reading
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How to Succeed in Digestive Research
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A Middle-aged Patient with a prolapsing rectal mass
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An unexpected guest in a patient with ulcerative colitis
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Adding Fuel to The Fire? A Role of Intraepithelial Lymphocytes in Enteric Immune Responses to SARS-CoV-2 Infection
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Positioning infliximab and vedolizumab in the treatment of moderate-to-severe ulcerative colitis
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Safety and Efficacy of Anti-TNF Therapy in Older Adults with Ulcerative Colitis: A New Path Forward
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The different immune profiles of normal colonic mucosa in cancer-free Lynch syndrome carriers and Lynch syndrome colorectal cancer patients
Due to the high load of immunogenic frameshift neoantigens, tumors arising in individuals with Lynch syndrome (LS), the most common inherited colorectal cancer (CRC) syndrome, are characterized by a pronounced immune infiltration. However, the immune s… Continue reading
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