Monthly Archives: January 2022
Failure to Achieve Target Drug Concentrations During Induction and Not HLA-DQA1*05 Carriage is Associated with Anti-Drug Antibody Formation in Patients with Inflammatory Bowel Disease
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Rising Incidence of Cancer of the Small Intestine: Overdiagnosis & Better Diagnosis of Low-Lethality Disease
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Achieving Health Equity through Digestive Diseases Research and Scientific Workforce Diversity
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Genetic Variation in Sugar Metabolism Confers a Protective Metabolic Profile
Dietary sugar intake is associated with various metabolic disorders. A study by Anderson et al describes an arctic population whose genetic variation in sucrase-isomaltase (SI), an intestinal sucrose breakdown enzyme, confers a healthier anthropometric… Continue reading
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Off-the-shelf PSCA-directed chimeric antigen receptor natural killer cell therapy to treat pancreatic cancer
Pancreatic cancer (PC) is the third leading cause of cancer-related death with a 5-year survival rate of approximately 10%. It typically presents as a late-stage incurable cancer and chemotherapy provides modest benefit. Here, we demonstrate the feasib… Continue reading
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Early life: an important window of susceptibility for colorectal cancer
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Design of clinical trials for mild-to-moderate ulcerative colitis
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“Broadening our understanding of the immune landscape in Lynch syndrome”
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Colorectal cancer screening in IBD – can characterization of GI microbiome signatures enhance neoplasia detection?
Current non-invasive CRC screening methods are not optimized for persons with IBD, requiring patients to undergo frequent interval screening via colonoscopy. Although colonoscopy-based screening reduces CRC incidence in IBD patients, rates of interval … Continue reading
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