Monthly Archives: February 2022
Design of clinical trials for mild-to-moderate Crohn’s disease
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Transitional anal cells mediate colonic re-epithelialization in colitis
Epithelial wound healing is compromised and represents an unleveraged therapeutic target in inflammatory bowel disease (IBD). Intestinal epithelial cells exhibit plasticity that facilitates dedifferentiation and repair during the response to injury. Ho… Continue reading
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Mucin 5AC-mediated CD44/ITGB1 clustering mobilizes adipose-derived mesenchymal stem cells to modulate pancreatic cancer stromal heterogeneity
Secreted mucin 5AC from pancreatic tumor systemically modulates adipose-derived mesenchymal stem cells and contributes towards stromal heterogeneity. Understanding Muc5ac-associated fibrotic phenotype may significantly impact the clinical outcomes of a… Continue reading
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Higher vs Standard Adalimumab Induction and Maintenance Dosing Regimens for Treatment of Ulcerative Colitis: SERENE UC Trial Results
SERENE UC evaluated the efficacy of higher adalimumab induction and maintenance dose regimens in patients with ulcerative colitis (UC). Continue reading
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Esophageal Motility Disorders: Current Approach to Diagnostics and Therapeutics
Dysphagia is a common symptom with significant impact on quality of life. Our diagnostic armamentarium was primarily limited to endoscopy and barium esophagram until the advent of manometric techniques in the 1970s, which provided the first reliable to… Continue reading
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Impact of COVID-19 on Screening Colonoscopy Utilization in a Large Integrated Health System
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Our New President – John M. Carethers, MD, AGAF
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Stromal HIF2 Regulates Immune Suppression in the Pancreatic Cancer Microenvironment
Pancreatic ductal adenocarcinoma (PDAC) has a hypoxic, immunosuppressive stroma, which contributes to its resistance to immune checkpoint blockade therapies. The hypoxia-inducible factors (HIFs) mediate the cellular response to hypoxia, but their role … Continue reading
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In Memoriam Em. Prof. Dr. Paul Rutgeerts (1948 -2020)
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Deep learning-based classification of hepatocellular nodular lesions on whole-slide histopathologic images
Hepatocellular nodular lesions (HNLs) constitute a heterogeneous group of disorders. Differential diagnosis among these lesions, especially high-grade dysplastic nodule (HGDN) and well differentiated hepatocellular carcinoma (WD-HCC), can be challengin… Continue reading
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