T helper 17 (Th17) cells play a key role in barrier protection in the gastrointestinal tract but are also key pathological drivers of Inflammatory Bowel Disease (IBD). Although a number of key transcription factors governing Th17 differentiation have been identified, the intracellular signaling pathways regulating Th17 differentiation are poorly understood. Given the highly druggable nature of many intracellular signaling pathways, understanding the signaling pathways involved in Th17 differentiation holds great promise to identify novel drug targets for the treatment of IBD.