Individuals diagnosed with Ulcerative Colitis (UC) often seek complementary lifestyle methods, such as diet and physical activity, to self-manage disease symptoms and respond to the psychosocial challenges of living with chronic illness. The Energy Adjusted Dietary Inflammatory Index (E-DIITM) measures the inflammatory potential of one’s food intake and has never been studied among the UC population. This study aimed to test the associations between E-DII scores, physical activity, and UC related health outcomes.