Monthly Archives: February 2022
Guselkumab for the treatment of Crohn’s disease: Induction results from the Phase 2 GALAXI-1 study
Guselkumab, a selective p19 interleukin-23 antagonist, is approved for the treatment of plaque psoriasis and psoriatic arthritis. This study evaluated the efficacy and safety of guselkumab in patients with moderately to severely active Crohn’s disease … Continue reading
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We thank Bekki et al and Bhagat et al for their comments on our article “Results of Early Transplantation for Alcohol-Related Cirrhosis: Integrated Addiction Treatment with Low Rate of Relapse”. Bekki et al pointed out a trend toward inferior graft sur…
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Higher vs Standard Adalimumab Induction Dosing Regimens and 2 Maintenance Strategies: Randomized SERENE CD Trial Results
Dose-optimization strategies for biologic therapies in Crohn’s disease (CD) are not well established. SERENE CD evaluated higher vs standard adalimumab induction dosing and clinically adjusted (CA) vs therapeutic drug monitoring (TDM) maintenance strat… Continue reading
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Diminished Piezo2-dependent tactile sensitivity occurs in aging human gut and slows gastrointestinal transit in mice.
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Understanding early-onset colorectal cancer: The role of obesity
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Adjusting BCLC staging system to the evolving landscape of Hepatocellular Carcinoma. A look to the future
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Correction
Dasgupta D, Nakao Y, Mauer AS, et al. IRE1A Stimulates Hepatocyte-Derived Extracellular Vesicles That Promote Inflammation in Mice With Steatohepatitis. Gastroenterology 2020;159:1487–1503. Continue reading
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Long-term risk for CRC in patients with index serrated polyps
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A Novel Translational Activation of HIF1α Promotes Pancreatic Cancer Growth through Glycolytic Reprogramming
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Ozanimod for the Treatment of Ulcerative Colitis
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