Monthly Archives: February 2022
INTERLEUKIN-17 RECEPTOR SIGNALING TO PANETH CELLS HELPS MAINTAIN INTESTINAL INTEGRITY AFTER GAMMA RADIATION INDUCED INJURY
IL-17A/F signaling through the IL-17RA/RC receptor complex plays a vital role in immunity and inflammation. The expression of IL-17RA/RC by diverse intestinal epithelial cell types including Paneth cells and the observation that therapies neutralizing … Continue reading
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ACUITY OF PEDIATRIC INFLAMMATORY BOWEL DISEASE ADMISSIONS PRE AND DURING THE COVID-19 PANDEMIC
The COVID19 pandemic has introduced new challenges to the diagnosis and management of pediatric Inflammatory Bowel Disease (IBD). Many patients have had limited access to their providers through telemedicine and may choose to delay non-emergent treatme… Continue reading
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THE USE OF IMMUNOSTAINING IN BIOPSIES TO EVALUATE EXPRESSION PATTERN AND PATHOPHYSIOLOGY ROLES OF ONCOSTATIN M AND ITS RECEPTOR BETA IN PEDIATRIC INFLAMMATORY BOWEL DISEASE
The mRNA expression of oncostatin M (OSM) in colonic tissue is raised in inflammatory bowel disease (IBD) and is mplicated in anti-TNF treatment resistance. OSM has multiple homeostatic functions with both pathogenic and protective roles. Still, its fu… Continue reading
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DEVELOPMENT AND VALIDATION OF A MACHINE LEARNING TOOL FOR EARLY DIAGNOSIS OF INFLAMMATORY BOWEL DISEASE IN THE PRIMARY CARE SETTING: A POPULATION BASED STUDY
Although 3,000,000 Americans are afflicted with Inflammatory Bowel Disease (IBD) encompassing Crohn’s Disease (CD) and Ulcerative Colitis (UC)1, timely diagnosis is a challenge due to non-specific and overlapping symptoms.2 More than 20% of patients ma… Continue reading
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AMINO ACID SENSING PATHWAYS IN INFLAMMATORY BOWEL DISEASE
IBD is a chronic inflammatory disease of the gastrointestinal tract affecting millions of people worldwide. The last few decades have seen rapid increase of IBD cases in the US contributing to exorbitant health-care costs and morbidity rates. IBD compr… Continue reading
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RISK FACTORS FOR DEVELOPMENT OF PROSTATE CANCER IN PATIENT WITH INFLAMMATORY BOWEL DISEASE (IBD)
Prostate cancer (PC) is a 2nd leading cause of cancer death in the USA among men. We aim to investigate incidence, characteristics, and risk factors for PC in patients diagnosed with Inflammatory bowel disease (IBD) using Cerner Health Facts, a nationa… Continue reading
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DIET-ASSOCIATED INFLAMMATION, PHYSICAL ACTIVITY, AND HEALTH-RELATED OUTCOMES IN ULCERATIVE COLITIS
Individuals diagnosed with Ulcerative Colitis (UC) often seek complementary lifestyle methods, such as diet and physical activity, to self-manage disease symptoms and respond to the psychosocial challenges of living with chronic illness. The Energy Adj… Continue reading
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UTILITY OF FIBROSCAN IN ULCERATIVE COLITIS?
Ulcerative colitis (UC) is associated with liver disorders due to various etiologies. Some are diagnosed on basis of deranged liver function tests, imaging, and/or histology. Data on fibroscan in UC is scarce. A previous study had shown no significant … Continue reading
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EFFECTIVENESS OF CROHN’S DISEASE EXCLUSION DIET FOR INDUCTION OF REMISSION IN CROHN’S DISEASE ADULT PATIENTS
The Crohn’s disease exclusion diet (CDED) has a well-documented effectiveness in inducing remission in active Crohn’s disease (CD) in children. However, the data for adult population are limited. The aim of the study was to evaluate the effectiveness o… Continue reading
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AUTOMATIC BLEEDING AND ULCER DETECTION FROM LIMITED QUALITY ANNOTATIONS IN ULCERATIVE COLITIS
Ulcerative colitis is an idiopathic inflammatory disorder affecting the mucosa of the colon with superficial erosions and ulcers associated with bleeding. Severity assessment using current scoring schemes such as UCEIS and MAYO relies on the subjective… Continue reading
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