Daily Archives: March 7, 2022

IRAK4 signaling drives resistance to checkpoint immunotherapy in pancreatic ductal adenocarcinoma

Posted on March 7, 2022 by Gastroenterology Journal

Checkpoint immunotherapy is largely ineffective in pancreatic ductal adenocarcinoma (PDAC). The innate immune NF-κB pathway promotes PDAC cell survival, stromal fibrosis and is driven by IRAK4, but its impact on tumor immunity has not been directly inv… Continue reading →

Posted in News | Comments Off on IRAK4 signaling drives resistance to checkpoint immunotherapy in pancreatic ductal adenocarcinoma