Daily Archives: June 11, 2022

METTL3 inhibits anti-tumor immunity by targeting m6A-BHLHE41-CXCL1/CXCR2 axis to promote colorectal cancer

Posted on June 11, 2022 by Gastroenterology Journal

N6-Methyladenosine (m6A) is the most prevalent RNA modification and recognized as an important epitranscriptomic mechanism in colorectal cancer (CRC). We aim to exploit whether and how tumor-intrinsic m6A modification drove by methyltransferase like 3 … Continue reading →

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Dysplastic stem cell plasticity functions as a driving force for neoplastic transformation of pre-cancerous gastric mucosa

Posted on June 11, 2022 by Gastroenterology Journal

Dysplasia carries a high risk of cancer development, however, the cellular mechanisms for dysplasia evolution to cancer are obscure. We have previously identified two putative dysplastic stem cell (DSC) populations, CD44v6neg/CD133+/CD166+ (DP) and CD4… Continue reading →

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