Radiomics-Based Machine Learning Models Can Detect Pancreatic Cancer on Prediagnostic CTs at a Substantial Lead Time Prior to Clinical Diagnosis

Our purpose was to detect pancreatic ductal adenocarcinoma (PDAC) at the prediagnostic stage (3-36 months prior to clinical diagnosis) using radiomics-based machine learning (ML) models, and to compare performance against radiologists in a case-control study.