Daily Archives: July 15, 2022
Microbial signaling in pathophysiology of disorders of gut-brain interaction
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Heterogeneity in Efficacy and Safety Endpoints for Pediatric Clinical Trials in Inflammatory Bowel Disease: A Need for Harmonization
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Pigmented Polypoid Lesion in a 24-year-old Female with Hematochezia
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A Liquid Biopsy Signature for the Detection of Patients with Early-Onset Colorectal Cancer
Early-onset colorectal cancer (EOCRC) is a distinct clinical and molecular entity with poor survival outcomes compared to late onset CRC (LOCRC). Although the incidence of EOCRC is rising, current CRC screening strategies have several limitations in di… Continue reading
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An exosome-based transcriptomic signature for noninvasive, early detection of patients with pancreatic ductal adenocarcinoma: A multicenter cohort study
Pancreatic ductal adenocarcinoma (PDAC) incidence is rising worldwide, and majority of patients present with an unresectable disease at initial diagnosis. Measurement of carbohydrate antigen 19-9 (CA19-9) levels lack adequate sensitivity and specificit… Continue reading
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Altered gut microbiome composition and function are associated with gut barrier dysfunction in healthy relatives of patients with Crohn’s disease
The gut microbiome has been suggested to play a role in gut barrier hemostasis, but data are scarce and limited to animal studies. Therefore, we aimed to assess if alterations in gut microbial composition and functional pathways are associated with gut… Continue reading
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A lesson in transcriptional plasticity: Classical identity is silenced, but not lost, in pancreatic ductal adenocarcinoma cell lines
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Upadacitinib the new Jak inhibitor in town
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Ustekinumab versus Adalimumab in patients with Crohn’s disease
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