Studies have reported abnormal gut microbiota or circulating metabolome associated with colorectal cancer (CRC), but it remains a challenge to capture the CRC-relevant features consistent across geographic regions. This is particularly the problem for metabolic traits of CRC, because the analyses generally use different platforms and laboratory methods, which poses a barrier to cross-dataset examination. In light of this, we wish to elucidate the microbial and metabolic signatures of CRC with broad population relevance.