Monthly Archives: July 2022
Diagnostic performance of a non-invasive breath test for colorectal cancer: COBRA1 study
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Navigating the Stormy Sea of Infected Necrotizing Pancreatitis: Are We There Yet? Well Almost!
Acute pancreatitis (AP) is associated with significant morbidity and mortality.1 The short-term outcomes in AP are determined both by systemic and local complications. Persistent organ failure, which defines the severity of AP, leads to a high mortalit… Continue reading
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Liver Stiffness on Magnetic Resonance Elastography and the MEFIB Index and Liver-Related Outcomes in Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis of Individual Participants
Magnetic resonance elastography (MRE) is an accurate biomarker of liver fibrosis, however, limited data characterize its association with clinical outcomes. We conducted individual participant data pooled meta-analysis (IPDMA) on patients with nonalcoh… Continue reading
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Integrated analysis of colorectal cancer reveals cross-cohort gut microbial signatures and associated serum metabolites
Studies have reported abnormal gut microbiota or circulating metabolome associated with colorectal cancer (CRC), but it remains a challenge to capture the CRC-relevant features consistent across geographic regions. This is particularly the problem for … Continue reading
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Malondialdehyde-acetaldehyde extracellular matrix protein adducts attenuate unfolded protein response during alcohol and smoking-induced pancreatitis
Epidemiological studies have established alcohol and smoking as independent risk factors for recurrent acute pancreatitis (RAP) and chronic pancreatitis (CP). However, the molecular players responsible for the progressive loss of pancreatic parenchyma … Continue reading
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CORE-IBD: A Multidisciplinary International Consensus Initiative to Develop a Core Outcome Set for Randomized Controlled Trials in Inflammatory Bowel Disease
Endpoints to determine the efficacy and safety of medical therapies for Crohn’s disease (CD) and ulcerative colitis (UC) are evolving. Given the heterogeneity in current outcome measures, harmonizing endpoints in a core outcome set (COS) for randomized… Continue reading
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Population-level metagenomics uncovers distinct effects of multiple medications on the human gut microbiome
Medication is a major determinant of human gut microbiome structure, and its overuse increases the risks of morbidity and mortality. However, effects of certain commonly prescribed drugs and multiple medications on the gut microbiome are still under in… Continue reading
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