Daily Archives: August 3, 2022
An Unusual Cause of Obstructive Jaundice
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HNF4A Defines Molecular Subtypes and Vulnerability to TGFβ-pathway Targeted Therapies in Cancers of the Distal Esophagus
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Histone deacetylase inhibition by gut microbe-generated short chain fatty acids entrains intestinal epithelial circadian rhythms
The circadian clock orchestrates ∼24-hour oscillations of gastrointestinal epithelial structure and function that drive diurnal rhythms in gut microbiota. Here, we use experimental and computational approaches in intestinal organoids to reveal reciproc… Continue reading
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Gut Microbiota Alter Visceral Pain Sensation and Inflammation via Modulation of Synthesis of Resolvin D1 in Colonic Tuft Cells.
Visceral hypersensitivity and low grade mucosal inflammation are frequently observed in a subpopulation of irritable bowel syndrome (IBS) patients. The responsible mechanism is unclear. Resolvins are a novel class of anti-inflammatory lipid mediators t… Continue reading
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The beauty and sorrow of using PPI in patients with cirrhosis
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