Daily Archives: August 7, 2022
Clinical manifestations and stool load of atypical enteropathogenic E. coli infections in U.S. children and adults.
There is debate whether atypical enteropathogenic E. coli (aEPEC) causes disease in adults. aEPEC is commonly detected in symptomatic and asymptomatic individuals. aEPEC, in contrast to typical EPEC, lacks bundle forming pili, altering its pathogenicit… Continue reading
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Combined MEK and STAT3 inhibition uncovers stromal plasticity by enriching for cancer-associated fibroblasts with mesenchymal stem cell-like features to overcome immunotherapy resistance in pancreatic cancer
We have shown that reciprocally activated RAS/MEK and JAK/STAT3 pathways mediate therapeutic resistance in pancreatic ductal adenocarcinoma (PDAC), while combined MEK and STAT3 inhibition (MEKi+STAT3i) overcomes such resistance and alters stromal archi… Continue reading
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The rising burden of inflammatory bowel disease in Denmark over two decades: a nationwide cohort study
Shifts in epidemiological stages of inflammatory bowel disease (IBD) carry implications towards understanding IBD etiology and managing clinical care. We conducted a temporal analysis of the epidemiology of IBD between 1995 and 2016 in the Danish natio… Continue reading
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