Monthly Archives: August 2022
Bile and Liver in Pregnancy:no one Split apart what God has joined together.
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Abdominal Unidentified Flying Object (AUFO)
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The Microbiome Modifies the Effect of Diet on Colorectal Cancer Incidence
Colorectal cancer (CRC) remains one of the most common types of cancer in the world. To the many factors that in combination contribute to CRC tumor formation, bacterial components of the microbiome are now part of this conversation. Indeed, during the… Continue reading
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Mycobiota Signatures and Colorectal Cancer: A True Association or Not?
The association between gut bacteria and colorectal cancer (CRC) has been intensively investigated in recent years with the identification of a list of putatively procarcinogenic bacteria (eg, Fusobacterium nucleatum, Escherichia coli, and more).1-3 Ho… Continue reading
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Aldehyde “Adduction” Explains Synergy of Smoking and Alcohol in Promoting Pancreatitis
Pancreatitis is the inflammatory disorder of the pancreas, which often forms a disease continuum starting with a so-called sentinel attack of acute pancreatitis (AP), followed by recurrent AP (RAP) episodes, and eventual progression to chronic pancreat… Continue reading
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An Unusual Cause of Obstructive Jaundice
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HNF4A Defines Molecular Subtypes and Vulnerability to TGFβ-pathway Targeted Therapies in Cancers of the Distal Esophagus
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Histone deacetylase inhibition by gut microbe-generated short chain fatty acids entrains intestinal epithelial circadian rhythms
The circadian clock orchestrates ∼24-hour oscillations of gastrointestinal epithelial structure and function that drive diurnal rhythms in gut microbiota. Here, we use experimental and computational approaches in intestinal organoids to reveal reciproc… Continue reading
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Gut Microbiota Alter Visceral Pain Sensation and Inflammation via Modulation of Synthesis of Resolvin D1 in Colonic Tuft Cells.
Visceral hypersensitivity and low grade mucosal inflammation are frequently observed in a subpopulation of irritable bowel syndrome (IBS) patients. The responsible mechanism is unclear. Resolvins are a novel class of anti-inflammatory lipid mediators t… Continue reading
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