Monthly Archives: September 2022
CME Exam 2: Small Intestinal Bacterial Overgrowth—Pathophysiology and Its Implications for Definition and Management
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Minimal risk of drug-induced liver injury with molnupiravir and ritonavir-boosted nirmatrelvir
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Inflammatory Bowel Disease is Associated with Prediagnostic Perturbances in Metabolic Pathways
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Th17 cell-derived amphiregulin promotes colitis-associated intestinal fibrosis through activation of mTOR and MEK in intestinal myofibroblasts
Intestinal fibrosis is a significant complication of Crohn’s disease (CD). Gut microbiota reactive Th17 cells are crucial in the pathogenesis of CD; however, how Th17 cells induce intestinal fibrosis is still not completely understood. Continue reading
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Molecular markers of response to anti-PD1 therapy in advanced hepatocellular carcinoma
Single agent anti-PD1 checkpoint inhibitors convey outstanding clinical benefits in a small fraction (∼20%) of patients with advanced hepatocellular carcinoma (aHCC) but the molecular mechanisms determining response are unknown. To fill this gap, we he… Continue reading
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Endoscopist Adenoma Detection Rates and their Correlation with Post-colonoscopy Colorectal Cancer
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