Obesity predisposes to type 2 diabetes (T2D) and non-alcoholic fatty liver disease (NAFLD), but underlying mechanisms are incompletely understood. Potassium channel tetramerization domain-containing protein 17 (Kctd17) levels are increased in livers from obese mice and humans. In this study, we investigated mechanism of increased Kctd17 and whether it is causal to obesity-induced metabolic complications.