Monthly Archives: November 2022
Dysregulated amino acid sensing drives colorectal cancer growth and metabolic reprogramming leading to chemoresistance.
CRC is a devastating disease highly modulated by dietary nutrients. mTORC1 contributes to tumor growth and limits therapy responses. Growth factor signaling is a major mechanism of mTORC1 activation. However, compensatory pathways exist to sustain mTOR… Continue reading
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Loss of SUV420H2-dependent chromatin compaction drives right-sided colon cancer progression
Epigenetic processes regulating gene expression contribute markedly to epithelial cell plasticity in colorectal carcinogenesis. The lysine methyltransferase SUV420H2 comprises an important regulator of epithelial plasticity and is primarily responsible… Continue reading
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N-glycosylation regulates intrinsic IFN-γ resistance in colorectal cancer: implications for immunotherapy.
Advanced colorectal carcinoma (CRC) is characterized by a high frequency of primary immune evasion and refractoriness to immunotherapy. Given the importance of IFN-γ in CRC immunosurveillance, we investigated whether and how acquired IFN-γ resistance i… Continue reading
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The Case for FLIP Panometry in Clinical Practice
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Hepatocyte Kctd17 inhibition ameliorates glucose intolerance and hepatic steatosis caused by obesity-induced Chrebp stabilization
Obesity predisposes to type 2 diabetes (T2D) and non-alcoholic fatty liver disease (NAFLD), but underlying mechanisms are incompletely understood. Potassium channel tetramerization domain-containing protein 17 (Kctd17) levels are increased in livers fr… Continue reading
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New Sections in Gastroenterology—Gastro Curbside Consult and Gastro Grand Rounds
We are pleased to announce 2 new sections of Gastroenterology: Gastro Curbside Consult and Gastro Grand Rounds. Continue reading
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Diarrhea, Colonic Stenoses and a Kinase Inhibitor
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OrganEx: a Promising solution for Rescuing Organs following Prolonged Ischemia
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Guardian, Intermediary, or Perpetrator? New insights into environmental exposure, the gut microbiome, and NAFLD
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Moderate fluid resuscitation is preferable in acute pancreatitis
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