Daily Archives: January 23, 2023
The evolutionary landscape of colorectal tumorigenesis: recent paradigms, models and hypotheses
Using colorectal cancer (CRC) as a model, we review some of the insights into cancer evolution afforded by cancer sequencing. These include: non-linear and neutral evolution; polyclonality of driver mutations and parallel evolution in adenomas, althoug… Continue reading
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Modulating the Microbiome for Disease Treatment
The central role of gut microbiota in the regulation of health and disease has been convincingly demonstrated. Polymicrobial inter-kingdom interactions between bacteria (the bacteriome) and fungal (the mycobiome) communities of the gut have become a pr… Continue reading
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Lynch syndrome genetics and clinical implications
Lynch syndrome (LS) is one of the most prevalent hereditary cancer syndromes in man and accounts for some 3% of unselected patients with colorectal or endometrial cancer and 10–15% of those with DNA mismatch repair (MMR)-deficient tumors. Previous stud… Continue reading
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