Monthly Archives: January 2023
The evolutionary landscape of colorectal tumorigenesis: recent paradigms, models and hypotheses
Using colorectal cancer (CRC) as a model, we review some of the insights into cancer evolution afforded by cancer sequencing. These include: non-linear and neutral evolution; polyclonality of driver mutations and parallel evolution in adenomas, althoug… Continue reading
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Modulating the Microbiome for Disease Treatment
The central role of gut microbiota in the regulation of health and disease has been convincingly demonstrated. Polymicrobial inter-kingdom interactions between bacteria (the bacteriome) and fungal (the mycobiome) communities of the gut have become a pr… Continue reading
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Lynch syndrome genetics and clinical implications
Lynch syndrome (LS) is one of the most prevalent hereditary cancer syndromes in man and accounts for some 3% of unselected patients with colorectal or endometrial cancer and 10–15% of those with DNA mismatch repair (MMR)-deficient tumors. Previous stud… Continue reading
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Repurposing UDCA, an FXR Inhibitor, to Prevent SARS-Cov-2 Infection
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The impact of proportional dietary carbohydrate and fat content upon type 2 diabetes and NAFLD.
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Identification of the γδ IEL-secreted Paneth cell protective factor API5 as a promising therapeutic target for ATG16L1-associated Crohn’s disease
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Circulating Mitochondrial DNA as a Diagnostic Biomarker for Predicting Disease Severity in Patients with Acute Pancreatitis
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Injectable, drug-eluting nanocrystals prevent fibrosis and stricture formation in vivo
Tissue fibrosis results from uncontrolled healing responses that results in excessive mesenchymal cell activation, collagen and other extracellular matrix (ECM) deposition. In the gastrointestinal (GI) tract, fibrosis leads to narrowing of the lumen an… Continue reading
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Recurrent lower abdominal pain, altered bowel habits and malaise: Conservative or surgical approach to a common disorder
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Response to the Letter to the Editor
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