Monthly Archives: January 2023
AGA Clinical Practice Update on Diagnosis and Management of Acute Hepatic Porphyrias: Expert Review
The acute hepatic porphyrias (AHP) are rare, inborn errors of heme-metabolism and include acute intermittent porphyria, hereditary coproporphyria, variegate porphyria, and porphyria due to severe deficiency of 5-aminolevulinic acid dehydratase. Acute i… Continue reading
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RE: Proton pump inhibitors and mortality
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Trypsin activity in secretagogue-induced murine pancreatitis is solely elicited by cathepsin B and does not mediate key pathologic responses
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Low Hepatitis B Core-Related Antigen Levels Correlate Higher Spontaneous Seroclearance of HBsAg in Chronic Hepatitis B Patients with High HBsAg Levels
Seroclearance of hepatitis B surface antigen (HBsAg) indicates functional cure for hepatitis B virus (HBV) infection. Low HBsAg levels can predict HBsAg seroclearance over time. However, little is known about the association between hepatitis B core-re… Continue reading
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F4/80+Ly6Chigh macrophages lead to cell plasticity and cancer initiation in colitis
Colorectal cancer (CRC) is a leading cause of cancer death with a major risk factor being chronic inflammation. Despite the link between colitis and cancer, the mechanism by which inflammation leads to CRC is not well understood. Continue reading
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Variation in testing for and incidence of celiac autoimmunity in Canada: A population-based study
Incidence of biopsy-confirmed celiac disease has increased. However, few studies have explored incidence of celiac autoimmunity based on positive serology. Continue reading
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Anti-integrin αvβ6 autoantibodies are a novel biomarker that antedate ulcerative colitis
Better biomarkers for prediction of ulcerative colitis (UC) development and prognostication are needed. Anti-integrin αvβ6 autoantibodies (anti-αvβ6) have been described in UC patients. Here, we tested for the presence of anti-αvβ6 antibodies in the pr… Continue reading
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Artificial Intelligence–Aided Colonoscopy for Characterizing and Detecting Colorectal Polyps: Required, Nice to Have, or Overhyped?
In recent years, there has been a litany of publications assessing the potential benefits of emerging artificial intelligence (AI) applications in improving select aspects of colonoscopy quality. This has especially been the case for tools to assist in… Continue reading
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Real-world implications of the AGA NAFLD Clinical Care Pathway in the US adult population
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Correction
Nagata N, Nishijima S, Miyoshi-Akiyama T, et al. Population-level Metagenomics Uncovers Distinct Effects of Multiple Medications on the Human Gut Microbiome. Gastroenterology 2022;163:1038–1052. Continue reading
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