Monthly Archives: February 2023

The idea that pancreatitis—a common, painful, and life-threatening disease1,2—is caused by the pancreas digesting itself is about 130 years old,3 and the foremost villain in this process is believed to be trypsin, a serine protease discovered even earl… Continue reading →

Aberrant DNA methylation is frequent in colorectal cancer (CRC), but underlying mechanisms and pathological consequences are poorly understood. Continue reading →

Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related death worldwide, but there is deficiency of early diagnosis biomarkers and therapeutic targets. Drug-resistance account for most HCC-related deaths, yet the mechanisms underl… Continue reading →

Non-alcoholic fatty liver disease (NAFLD) can progress to cirrhosis and hepatic decompensation, but whether genetic variants influence the rate of progression to cirrhosis or are useful in risk stratification among patients with NAFLD is uncertain. Continue reading →

Hereditary Diffuse Gastric Cancer (HDGC) is a dominantly-inherited cancer syndrome characterized by a high incidence of diffuse gastric cancer (DGC) and lobular breast cancer (LBC). HDGC is caused by germline mutations in two genes involved in the epit… Continue reading →

Endoscopic surveillance of Barrett’s esophagus (BE), aiming to detect prevalent dysplasia and adenocarcinoma, followed by effective endoscopic treatment, is an integral part of the esophageal adenocarcinoma (EAC) prevention paradigm. However, several l… Continue reading →

Transformation of stem/progenitor cells has been associated with tumorigenesis in multiple tissues, but in the stomach stem cells have been hard to localize. We therefore aimed to use a combination of several markers in order to better target oncogenes… Continue reading →