Monthly Archives: March 2023
Disposable Elevator Caps Reduce Microbial Contamination after ERCP
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Is the Quantification of Interstitial Cells of Cajal in Gastric Biopsies in Patients with Gastroparesis Ready for Prime Time?
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Onco-microbial community profiling identifies clinico-molecular and prognostic subtypes of colorectal cancer
Dysbiosis of gut microbiota is linked to the development of colorectal cancer (CRC). However, microbiota-based stratification of CRC tissue and how this relates to clinico-molecular characteristics and prognosis remains to be clarified. Continue reading
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Molecular profile of MSH6-associated colorectal carcinomas shows distinct features from other Lynch syndrome-associated colorectal carcinomas
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Single-cell Profiling of Tumor Immune Microenvironment Reveals Immune Irresponsiveness in Gastric Signet-ring Cell Carcinoma
Gastric cancer (GC) is a major cancer type characterized by high heterogeneity in both tumor cells and the tumor immune microenvironment (TIME). One intractable GC subtype is gastric signet-ring cell carcinoma (GSRCC), which is associated with poor pro… Continue reading
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A “two-in-one hit” model of shortcut carcinogenesis in MLH1 Lynch syndrome carriers
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The efficacy of peroral endoscopic myotomy vs. pneumatic dilation as treatment for patients with achalasia suffering from persistent or recurrent symptoms after laparoscopic Heller myotomy. A RANDOMIZED CLINICAL TRIAL
For achalasia patients with persistent or recurrent symptoms after laparoscopic Heller myotomy (LHM), pneumatic dilation (PD) is the most frequently used treatment. Per-oral endoscopic myotomy (POEM) is increasingly being investigated as rescue therapy… Continue reading
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BMPR2 as a novel predisposition gene for hereditary colorectal polyposis
Colorectal cancer (CRC) is one of the most prevalent tumours worldwide, with incidences (particularly in the context of early-onset cases) quickly increasing despite important prevention efforts, mainly in the form of population-wide screening programm… Continue reading
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A TEAD2-driven endothelial-like program shapes basal-like differentiation and metastasis of pancreatic cancer
Pancreatic ductal adenocarcinoma (PDA), with its highly metastatic propensity, is one of the most lethal subtypes of pancreatic cancer. Although recent large-scale transcriptomic studies have demonstrated that heterogeneous gene expressions play an ess… Continue reading
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Lymphatic invasion of plakoglobin-dependent tumor cell clusters drives formation of polyclonal lung metastases in colon cancer
Colon cancer patients with liver metastases may be cured by surgery, but the presence of additional lung metastases often precludes curative treatment. Little is known about the processes driving lung metastasis. This study aimed to elucidate the mecha… Continue reading
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