Current methods to monitor inflammatory bowel disease (IBD) activity, such as colonoscopy, blood and stool markers, or imaging, are suboptimal and rely on single timepoint assessments that are inconvenient, expensive, or invasive. Wearable devices are a highly scalable mobile health technology that can non-invasively, continuously, and accurately monitor several physiological parameters that have been linked to flare in IBD. We performed a pilot feasibility study in subjects with IBD of a wearable device to monitor sweat-based inflammatory markers.