Two recent randomized controlled trials published in Gastroenterology indicated inconsistent results in the treatment of ulcerative colitis by fecal microbiota transplantation (FMT).1,2 Moayyedi et al1 reported a significant efficacy of FMT in inducing the remission of ulcerative colitis activity, with the 24% in FMT group compared with 5% in placebo group, whereas Rossen et al2 reported that there was no difference in clinical and endoscopic remission between the patients who received FMT with feces from healthy donor and patients who received FMT with autologous feces.