Dietary soluble fibers have many beneficial effects on gastrointestinal (GI) health; however, the mechanisms by which these fibers attenuate intestinal inflammation during colitis remains elusive. We propose that fiber-derived gut metabolites diminish intestinal inflammation via regulating NOD-like-receptor C4 (NLRC4) inflammasome signaling in the GI tract. To demonstrate this, C57BL/6 mice were fed either dietary cellulose (insoluble fiber) or pectin (soluble fiber) and administered three weekly injections of IL-10 receptor neutralizing antibody (α-IL-10R) to induce chronic colitis.