Inflammatory bowel diseases (IBD) are chronic intestinal diseases affecting over 1.4 million Americans. Children and adolescents typically have more severe disease and are more likely to display extra-intestinal effects, including psychosocial deficits, compared to adult patients. Unfortunately, the mechanism(s) through which these extra-intestinal deficits develop is unknown and murine models of pediatric IBD do not exist. Our overall goal was to develop a model of pediatric IBD and assess the microbiota-gut-brain axis in adolescent mice.