Identifying active small bowel Crohn’s Disease (CD) is often challenging due various reasons. The location of Crohn’s disease and often the disease process itself make direct visualization difficult. Fecal calprotectin (FCP) is a well-established marker of mucosal inflammation. Several studies have confirmed FCP’s utility in colonic inflammation; however, the diagnostic accuracy in active small bowel inflammation had yet to be established. The aim of the present study is to update the previous meta-analysis of FCP and its diagnostic accuracy in detecting active small bowel Crohn’s disease.