Colorectal cancer (CRC) is an important preventable malignancy, with >1 million prevalent cases and >50,000 annual attributable deaths in the United States alone.1 Fortunately, CRC deaths can be prevented with screening.2,3 However, currently available screening tests are imperfect and not without risk, and screening cannot prevent all CRC owing to access issues and other limitations. Screening is also a form of secondary prevention, working to detect cancers after they have already formed.