Alcoholic fatty liver disease (ALD) and nonalcoholic fatty liver disease (NAFLD) are 2 of the most common and important liver diseases facing physicians in the 21st century. Because they are so histologically similar, there is a common belief that ALD and NAFLD must share pathogenic mechanisms. In their book, Alcoholic and Non-Alcoholic Fatty Liver Disease: Bench to Bedside, Drs Chalasani and Gyongyi present a comprehensive review of these 2 diseases from bench to bedside, which will appeal to a very broad audience from medical students to seasoned investigators.