The importance of Barrett’s esophagus lies in its potential for malignant conversion to invasive esophageal adenocarcinoma (EA), a cancer with an extremely poor prognosis. Although a relatively rare event, with a progression risk of <1 per 300 patients with nondysplastic Barrett’s per year,1,2 esophageal cancer deaths contribute a nontrivial excess lifetime mortality risk for such patients. The lack of successful treatments for advanced disease indicate that prevention is a highly important strategy to improve outcomes.