Perianal Crohn’s disease (CD), affecting nearly one-third of patients with CD, is a highly morbid condition owing to incontinence, perianal pain, recurrent infection, and decreased quality of life.1 Notoriously difficult to treat, patients are left cycling through immunosuppressives fraught with risk of opportunistic infection and multiple perianal procedures laden with risk of incontinence,2 desperate to alleviate their symptoms. Fortunately, regenerative medicine, or the ability to use one’s own tissue to restore a healthy state, is a rapidly expanding field, and its application to CD is no exception.