IκB kinase-β (IKKβ) mediates activation of the nuclear factor-κB (NFκB), which regulates immune and inflammatory responses. Although NFκB is activated in cells from patients with inflammatory diseases or cancer, little is known about its roles in development and progression of esophageal diseases. We investigated whether mice that express an activated form of IKKβ in the esophageal epithelia develop esophageal disorders.
Esophageal Expression of Active IκB kinase-β in Mice Upregulates Tumor Necrosis Factor and Granulocyte Macrophage Colony-stimulating Factor, Promoting Inflammation and Angiogenesis
Esophageal Expression of Active IκB kinase-β in Mice Upregulates Tumor Necrosis Factor and Granulocyte Macrophage Colony-stimulating Factor, Promoting Inflammation and Angiogenesis
IκB kinase-β (IKKβ) mediates activation of the nuclear factor-κB (NFκB), which regulates immune and inflammatory responses. Although NFκB is activated in cells from patients with inflammatory diseases or cancer, little is known about its roles in development and progression of esophageal diseases. We investigated whether mice that express an activated form of IKKβ in the esophageal epithelia develop esophageal disorders.