Gastric cancer (GC) is the third leading cause of global cancer mortality. Adenosine-to-Inosine (A-to-I) RNA editing is a recently-described novel epigenetic mechanism involving sequence alterations at the RNA but not DNA level, primarily mediated by ADAR enzymes (Adenosine DeAminase that act on RNA). Emerging evidence suggests a role for RNA editing and ADARs in cancer, however the relation between RNA editing and GC development and progression remains unknown.