mTORC1 Up-Regulates GP73 to Promote Proliferation and Migration of Hepatocellular Carcinoma Cells and Growth of Xenograft Tumors in Mice

Posted on May 13, 2015 by Xinxin Chen, Yanan Wang, Jun Tao, Yuzhuo Shi, Xiaochen Gai, Fuqiang Huang, Qian Ma, Zhenzhen Zhou, Hongyu Chen, Haihong Zhang, Zhibo Liu, Qian Sun, Haiyong Peng, Rongrong Chen, Yanling Jing, Huayu Yang, Yilei Mao, Hongbing Zhang

Levels of the Golgi protein 73 (GP73) increase during development of hepatocellular carcinoma (HCC); GP73 now is used as a serum marker for HCC. However, little is known about the mechanisms or effects of GP73 during hepatic carcinogenesis.

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