Coordinated contractions of the stomach are integrated motor responses classically described as consisting of “neurogenic” and “myogenic” components. In the last 2 decades, dissection of the myogenic elements using genetic, molecular, morphologic, and physiologic approaches have identified several cells types that contribute to this component of gastrointestinal (GI) motility. Interstitial cells of Cajal (ICC) are recognized as major contributors to GI motor activity.1 These cells are gastric pacemakers and act as neuroeffectors between enteric motor nerve terminals and smooth muscle cells (SMC).