Inflammatory bowel diseases, such as Crohn’s disease (CD) and ulcerative colitis, lead to severe complaints including diarrhea, rectal bleeding, abdominal pain, fatigue, or weight loss in affected patients. These symptoms are caused by a chronic relapsing inflammatory process within the intestinal wall. Acute aggravations of Inflammatory bowel disease need frequent adjustments or changes in therapy to reduce symptoms and prevent severe complications. To enable a quick and appropriate change of therapy, reliable and accurate methods are required to provide an objective assessment of disease activity.