As principal investigators of an ongoing randomized study evaluating different ablation regimens for the Barrx 360 express RFA balloon catheter (360 Express; GI solutions Covidien/Medtronic, Sunnyvale, CA), we feel the responsibility to communicate our interim finding of an unexpected high rate of severe esophageal stenosis when using the 360 Express with a simplified 2 × 10 J/cm2 no clean ablation regimen.