Question: A 22-year-old woman with no past medical history was investigated for hypoglycemia episodes. A nodule located in the head of the pancreas was identified, with radiologic features of a neuroendocrine neoplasm. The overall clinical presentation was consistent with an insulinoma. No distant lesion was detected. She underwent a Whipple’s procedure, and the histopathological examination reported a 2.2-cm, well-differentiated neuroendocrine tumor (insulinoma) G2 (4% Ki-67 index), with no lymphovascular invasion or lymph nodes metastasis (0 of 30 lymph nodes).