Societal recommendations rely on age and life expectancy to guide clinicians on the potential mortality benefit of continued colorectal cancer (CRC) screening. Up to 40% of patients undergoing screening colonoscopy have less than a 10-year life expectancy, highlighting this clinical challenge. The Charlson Comorbidity Index (CCI) has been utilized to prognosticate mortality for a number of conditions but has not been examined for use in screening colonoscopy recommendations. We sought to examine whether CCI could be used to predict patient death (i.e., patients who should discontinue colonoscopy) prior to the recommended screening or surveillance procedure.